49ers Rush to Ignite “Blockbuster” Deal for NFL’s Top DE to Replace Nick Bosa, Affirming Super Bowl LXI Ambitions

San Francisco, September 23, 2025

The San Francisco 49ers are facing a major shock as defensive star Nick Bosa suffered a torn anterior cruciate ligament (ACL) and is officially out for the entire 2025 season. Losing their frontline leader, the team is forced to consider an immediate replacement option. The name most frequently mentioned is Trey Hendrickson, defensive end of the Cincinnati Bengals – who had an explosive 2024 season with 17.5 sacks and an All-Pro selection.

Hendrickson is regarded as one of the NFL’s most effective pass rushers, possessing speed and strength to consistently pressure quarterbacks. With his contract situation at the Bengals still lacking a long-term resolution, multiple sources suggest the 49ers may be contemplating a blockbuster trade to fill the void left by Bosa.

In the context of Kyle Shanahan’s system, bringing in Hendrickson makes complete sense. San Francisco’s defense heavily relies on pressure from the front line, and with Bosa sidelined, the team needs a figure of sufficient stature to maintain that strength. Hendrickson, with his extensive experience and consistent performance, is one of the few names on the market capable of helping the 49ers sustain their ambitions.

The 49ers general manager said in response to the trade rumors: "We'll look at every possibility in the market, from internal to trade assignments. If there's an opportunity that really helps the team, I'll do everything secondary to bring it to San Francisco."

However, the price will certainly not be cheap. Some experts predict the 49ers would have to part with a valuable draft pick package, with rumors even involving quarterback Mac Jones. That said, it must be emphasized that all of this remains at the level of media speculation, with no official confirmation from either team.

With San Francisco currently undefeated and aiming for Super Bowl LXI, a bold move is entirely possible. If the Hendrickson trade comes to fruition, the 49ers will send a clear message: they are ready to do whatever it takes to conquer the ultimate title.