49ers WR Suffers Double Injury Ahead of Week 16, Still Determined to Play for 49ers Against Colts
San Francisco, California — December 18, 2025
The San Francisco 49ers enter Week 16 at a delicate point in their season. Their matchup with the Indianapolis Colts carries significant playoff implications and comes at a time when the team’s injury list continues to grow. Christian McCaffrey and Trent Williams were given veteran rest, while several key contributors on both sides of the ball were limited in practice. Amid that backdrop, concerns surrounding Ricky Pearsall have emerged as the most pressing issue for the coaching staff.

According to the team’s early-week injury report, Pearsall did not participate in the first practice session preparing for Monday Night Football due to a double injury: a new ankle issue that has also aggravated a preexisting PCL injury in his knee. For a wide receiver, that combination presents a significant challenge, directly affecting cutting ability, burst, and balance — all essential elements of Pearsall’s game.
From a tactical standpoint, Pearsall’s presence means far more than raw statistics. He is a precise route-runner who creates separation in the intermediate areas of the field and provides Brock Purdy with a reliable option against pressure. With the 49ers lacking consistent depth at wide receiver following recent personnel changes, Pearsall has become a key connector within Kyle Shanahan’s offensive system, helping stretch defenses and open space for Deebo Samuel and the tight ends.
Behind the schematic value, however, lies a deeply human moment. According to team sources, Pearsall was visibly emotional in the locker room after realizing both the severity of the pain and the possibility of missing one of the most important games of the season. It was not only the physical toll, but the weight of potentially being unavailable when his teammates need him most. Still, Pearsall made his mindset clear.
“I know my body better than anyone, and it’s frustrating when injuries keep stacking up,” Pearsall said. “But this is the time when the team needs everyone. If I can push through the pain and help the team in any way, even a little, I’m willing to do that.”
The 49ers coaching staff remains cautious but not pessimistic. Head coach Kyle Shanahan indicated that Pearsall’s condition has improved compared to earlier in the week, and the Monday night kickoff provides an extra day of recovery. The team will continue to evaluate him on a day-to-day basis, prioritizing long-term health while leaving the door open for Pearsall to be cleared if he passes late-week testing.
If Pearsall is unable to play or is limited, San Francisco may need to adjust its offensive approach, increasing responsibilities for Jauan Jennings, Jacob Cowing, or asking Deebo Samuel to take on additional roles across the formation. Even so, there is little debate inside the locker room that Pearsall’s absence would create a noticeable void within the offensive structure.
Ultimately, Pearsall’s situation ahead of Week 16 is more than a routine injury update. It reflects the pressure, sacrifice, and difficult decisions faced by players late in the season. Whether he takes the field against the Colts or not, Pearsall’s determination embodies the identity of a 49ers team fighting through adversity as it pushes toward the postseason.
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