Injury Storm Sweeps Through San Francisco: 49ers Lose Mykel Williams, Brock Purdy Continues to Sound Alarm – But the Fighting Spirit Does Not Back Down

San Francisco, November 2025

The San Francisco 49ers are going through the most grueling phase of the 2025 season. Just days after confirming defensive rookie Mykel Williams will miss the rest of the season due to an ACL injury, the team has received another blow: QB Brock Purdy is facing complications with his toe injury and will likely have to endure this issue for the remainder of the season.

Williams, the No. 11 pick in the 2025 NFL Draft, was expected to become a new spearhead on the defensive line after Nick Bosa's long-term absence. However, the injury in the win over the Giants has put his breakout dreams on hold. Losing a high-potential player like Williams in this critical phase is a heavy blow to an already worn-down defense.

But the worries do not stop there. Head coach Kyle Shanahan confirmed Brock Purdy – who was hoped to return for the Giants game – is still not ready to play. Purdy’s turf toe injury has become complicated and could drag on until the end of the season, forcing the 49ers to continue placing their trust in Mac Jones.

“This is the cruel part of football,” Shanahan admitted. “We’re losing great warriors. Mykel is a guy who works extremely hard, and Brock – everyone knows he’s the heart of the team. But we won’t complain. No excuses. The 49ers will keep getting up and fighting.”

When asked if the injury storm would diminish San Francisco’s playoff ambitions, Shanahan was resolute:

“We have never and will never give up. This is the 49ers. We move forward – no matter how tough it gets.”

Despite the enormous losses, the spirit of the entire team and Shanahan himself gives fans reason to believe. San Francisco has faced adversity before, and if there’s any team that knows how to win when backed into a corner – it’s the 49ers.

Ahead lies a brutal playoff race. And if the 49ers want to write a special comeback story, they will have to overcome the biggest challenge: standing firm when the injury storm rages fiercest.

The storm has arrived – but the 49ers keep marching forward.