Time Update: 49ers vs Colts Set for Monday Night Football — A Crucial Showdown With Playoff Implications
Dec 22, 2025
INDIANAPOLIS, Indiana – The NFL has officially confirmed kickoff details for one of Week 16’s most anticipated matchups, as the San Francisco 49ers travel to face the Indianapolis Colts in a Monday Night Football showdown at Lucas Oil Stadium.
The game is scheduled to kick off at 8:15 p.m. ET on Monday, December 22, and will be broadcast nationally on ESPN, ABC, ESPN Deportes, with streaming available on Disney+.

49ers vs. Colts: Monday Night Stage Is Set
With the regular season winding down, this matchup arrives at a critical moment for both teams — particularly for San Francisco, who enter Week 16 riding a four-game winning streak and holding a 10–4 record.
The 49ers have surged back into strong playoff position despite a season riddled with injuries, and Monday night represents another opportunity to solidify their standing in the NFC playoff race. A win in Indianapolis would keep momentum rolling and maintain pressure on the top teams in the conference.
For the Colts, this game carries equal weight. Indianapolis remains firmly in the hunt in the AFC South, and playing at home inside the dome gives them a controlled environment to challenge one of the league’s hottest teams.
Why the NFL Put This Game in Prime Time
The league’s decision to spotlight this game in the Monday night window reflects the current landscape of the playoff race.
San Francisco’s offense, led by Brock Purdy, has found its rhythm at the perfect time, while the defense continues to deliver timely stops. The Colts, meanwhile, are fighting to keep their postseason hopes alive in a tightly contested division.
Unlike outdoor winter matchups, Lucas Oil Stadium’s retractable roof ensures weather will not be a factor — a key detail for fans and teams alike, especially with Indianapolis facing freezing temperatures outside.
Key Game-Day Information for Fans
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Kickoff: 8:15 p.m. ET
Date: Monday, December 22, 2025
Venue: Lucas Oil Stadium (indoor), Indianapolis
TV: ESPN, ABC, ESPN Deportes
Streaming: Disney+
Stadium gates are set to open at 6:15 p.m. ET, with fan activities beginning earlier in the afternoon. Fans attending the game are encouraged to arrive early, as winter traffic conditions could impact travel.
A Night That Could Shape the Postseason
This isn’t just another late-season game.
For the 49ers, it’s a chance to keep their surge alive and strengthen playoff positioning.
For the Colts, it’s an opportunity to defend home turf and stay in the AFC South race.
Monday Night Football. Prime time. Indoors.
Two teams with everything on the line.
49ers. Colts. 8:15 p.m. ET.
December football doesn’t get much bigger than this.













