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Time Update: 49ers vs Colts Set for Monday Night Football — A Crucial Showdown With Playoff Implications

Dec 22, 2025

INDIANAPOLIS, Indiana – The NFL has officially confirmed kickoff details for one of Week 16’s most anticipated matchups, as the San Francisco 49ers travel to face the Indianapolis Colts in a Monday Night Football showdown at Lucas Oil Stadium.

The game is scheduled to kick off at 8:15 p.m. ET on Monday, December 22, and will be broadcast nationally on ESPN, ABC, ESPN Deportes, with streaming available on Disney+.

49ers vs. Colts: Monday Night Stage Is Set

With the regular season winding down, this matchup arrives at a critical moment for both teams — particularly for San Francisco, who enter Week 16 riding a four-game winning streak and holding a 10–4 record.

The 49ers have surged back into strong playoff position despite a season riddled with injuries, and Monday night represents another opportunity to solidify their standing in the NFC playoff race. A win in Indianapolis would keep momentum rolling and maintain pressure on the top teams in the conference.

For the Colts, this game carries equal weight. Indianapolis remains firmly in the hunt in the AFC South, and playing at home inside the dome gives them a controlled environment to challenge one of the league’s hottest teams.

Why the NFL Put This Game in Prime Time

The league’s decision to spotlight this game in the Monday night window reflects the current landscape of the playoff race.

San Francisco’s offense, led by Brock Purdy, has found its rhythm at the perfect time, while the defense continues to deliver timely stops. The Colts, meanwhile, are fighting to keep their postseason hopes alive in a tightly contested division.

Unlike outdoor winter matchups, Lucas Oil Stadium’s retractable roof ensures weather will not be a factor — a key detail for fans and teams alike, especially with Indianapolis facing freezing temperatures outside.

Key Game-Day Information for Fans

  • Kickoff: 8:15 p.m. ET

  • Date: Monday, December 22, 2025

  • Venue: Lucas Oil Stadium (indoor), Indianapolis

  • TV: ESPN, ABC, ESPN Deportes

  • Streaming: Disney+

  • Stadium gates are set to open at 6:15 p.m. ET, with fan activities beginning earlier in the afternoon. Fans attending the game are encouraged to arrive early, as winter traffic conditions could impact travel.

    A Night That Could Shape the Postseason

    This isn’t just another late-season game.

    For the 49ers, it’s a chance to keep their surge alive and strengthen playoff positioning.
    For the Colts, it’s an opportunity to defend home turf and stay in the AFC South race.

    Monday Night Football. Prime time. Indoors.
    Two teams with everything on the line.

    49ers. Colts. 8:15 p.m. ET.
    December football doesn’t get much bigger than this.

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    Firefighter Passed Away in the Line of Duty Protecting the City of San Francisco — As 49ers Faithful Welcome the New Year, One Hero Is Left Behind in 2025
    Jan 1, 2026 Share this article:Share on FacebookShare on TwitterShare on LinkedInShare on WhatsAppCopy link San Francisco, California – As downtown streets began to glow with New Year’s lights and countdowns echoed across the Bay Area, San Francisco suddenly slowed into a moment of silence. Not because of fog. Not because of a game or a celebration put on hold. The city paused because one quiet question began spreading from neighborhood to neighborhood: Who didn’t make it into the new year with us? That question now has a name. Danny Cook. He wasn’t a star athlete. He never appeared on scoreboards or national television. But in the moments when danger forced everyone else to step back, Cook stepped forward. A San Francisco firefighter, Cook passed away while on duty, leaving behind a city — and 49ers Faithful — struggling to reconcile celebration with loss, joy with gratitude, and hope with grief. Forward progress stopped on the #DannyFire northwest of #Lancaster. Fire burned more than 1,500 acres and a barn but crews kept it from spreading to a nearby house. Helicopters including @CoulsonAviation helitankers, LA County and @LAFD air units were also on scene. @kcalnews pic.twitter.com/Pl1aHpHkrK — John Schreiber (@johnschreiber) June 5, 2023 According to officials, Danny Cook suffered a severe medical emergency while responding to an emergency call. His fellow firefighters immediately initiated life-saving measures at the scene, working against the clock before he was transported to a nearby hospital. Despite exhaustive efforts by fire and medical personnel, Cook passed away during his shift — in service, bound by the oath he lived by. For the San Francisco Fire Department, this was not simply a line-of-duty passing. It was the loss of a brother. A firefighter trusted with lives in the most unforgiving moments. A steady presence when chaos threatened to overwhelm. In this profession, there are no spotlights and no applause — only discipline, courage, and an unspoken promise to protect others at any cost. That loss rippled quickly across the city. From quiet residential streets to the heart of downtown, San Francisco was reminded of a difficult truth: the safety it enjoys every day is sometimes purchased through silent sacrifice. As families prepared to raise a glass to welcome 2026, one family crossed into the new year with an empty chair — and an entire city aware of the debt it owes. A representative of the San Francisco 49ers shared a message of remembrance on behalf of the organization and the community: “San Francisco stands united with the family, friends, and fellow firefighters of Danny Cook. He represents the very best of this city — toughness, selflessness, and a willingness to protect others at all costs. His sacrifice will never be forgotten.” In sports, we often talk about moments that change games. But some people don’t change scoreboards — they change lives. Danny Cook never sought recognition, yet leaves behind a legacy measured in service, courage, and selflessness. His bravery didn’t need an audience to matter. San Francisco will move forward.The city will celebrate, rebuild, and hope again. But 2025 will forever be the year Danny Cook stayed behind — woven permanently into the soul of the city he gave everything to protect.